The world number one averaged just under 111 in a fabulous 13-2 victory against the Welsh youngster at the Winter Gardens.
And the bookies favourite, who hit five 180s, was delighted to have put on a show.
“That as the kind of performance I wanted to do. I’m really pleased,” said van Gerwen, who is chasing his maiden World Matchplay title.
“I feel really confident. I want to continue like this and I’m already looking forward to playing Ian White on Thursday.
“Three years ago I reached the quarter-finals, two years ago the semi-finals and last year I reached the final so I’m determined to make it my year this time.”
van Gerwen raced into a 4-1 lead and continued to make light work of his opponent after the first break as finishes of 91, 87 and 100 helped him win all five legs in the second session.
The Dutchman then took out 89 to move 10-1 ahead before Lewis pulled a leg back.
But van Gerwen ruthlessly rattled off the last three legs to complete the win with his highest ever average in Blackpool (110.93), which is the fourth highest three-dart average ever recorded at the Matchplay.