The world number one moved into Sunday’s quarter-finals with a 10-3 triumph, averaging over 107 in the process.
“I’m very happy with my game at the moment,” said van Gerwen, who faces Dave Chisnall in the last eight.
“I know I have got more in the tank and I hope I will find it and win the next match and the tournament,.
“Cristo has done very well for his first year in the PDC and I knew I could not underestimate his talent.
“I got the job done and I’m looking forward to the final day. I really want to get my hands on the trophy again.”
van Gerwen dominated early on, taking a commanding 4-1 lead and he went on to increase that advantage to 7-3 with Reyes taking out 83, 96 and 88 for those three legs.
van Gerwen fired in his fifth 180 to help him complete a 10-dart-leg as he moved five clear.
He followed that with an 11-darter before landing double eight for the win.